Possible Interaction: Glipizide and Glucose

“Chronic administration of glipizide GITS attenuated serum glucose responses to oral glucose challenge at 12 and 24 months when compared to baseline (0 months).”

“There was a marked decrease in the dextrose infusion rate with administration of either repaglinide or glipizide at hypoglycemia compared with drug administration at euglycemia (P </= 0.006).”

“ Glipizide stimulated insulin secretion and reduced glucose and xylose levels significantly with both routes of administration.”

“ Glipizide (10-100 muM) AND TOLBUTAMIDE (400 MUM) inhibited the stimulatory effect of glucose , dbcAMP, and theophylline on [3H]leucine incorporation into IRI.”

“Results: Healthy controls showed a robust C‐peptide increase after both glucose and glipizide , but NDM subjects showed a large increase in C‐peptide only following glipizide.”

“Studies with glimepiride (1) and glipizide (2) show falls in fasting glucose of 40–50 mg/dl and in A1C by 1.5%—with monotherapy controlling 25–30% of patients—which he characterized as “a very good effect, initially.””

“CONCLUSIONS The … indicated that glipizide treatment was … increase in fractional glucose metabolic rate at a basal insulin concentration (29 ± 3 to 42 ± 2 ml · m−2 · min−1, P < 0.… to the incremental change in SSPI (14 ± 4 to 23 ± 3 ml · m−2 · min−1, P < 0.02).”

“A significant relationship was found between the increase in C-peptide plasma levels and the decrease in glycemic profile after glucose load following glipizide treatment.”

“High doses of glipizide may impair, rather than improve, glucose balance.”

“In lean rat …, the presence of glipizide in the incubation medium caused a dose-dependent inhibition of the rate of lactate conversion to glucose (maximal inhibition=46%; EC50 value=26 microM), and simultaneously raised the cellular content of fructose-2,6-bisphosphate (maximal increment=40%; EC50 value=10 microM).”