“Clinical trials indicate …’s wort Hypericum perforatum ), via cytochrome P450 (CYP) and/or P-glycoprotein induction, reduces the plasma concentrations (… the clearance) of alprazolam, amitriptyline, atorvastatin, chlorzoxazone, ciclosporin, debrisoquine, digoxin, erythromycin, fexofenadine, gliclazide , imatinib, indinavir, irinotecan, ivabradine, mephenytoin, methadone, midazolam, nifedipine, …, quazepam, simvastatin, tacrolimus, talinolol, verapamil, voriconazole and warfarin.”