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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Gliclazide
supplement:
Glucose
Research Papers that Mention the Interaction
“ Gliclazide further reduced plasma glucose, the incremental area above baseline, and EGP during glucose infusion , while plasma insulin and C-peptide achieved higher plateaus (p < 0.05).”
Mechanisms of acute and chronic hypoglycemic action of gliclazide“Fasting insulin to glucose ratio significantly improved after gliclazide (P < 0.006).”
“Glycaemic control did not improve significantly during the observed period on metformin but lower concentrations of fasting glucose and total glycosylated haemoglobin were achieved with gliclazide.”
“ Gliclazide at concentrations of 10 to 1000 Μg/ml increased (p<0.05) the basal glucose uptake.”
Sulphonylurea stimulates glucose uptake in rats through an ATP-sensitive K+ channel dependent mechanism“ Gliclazide had a weaker effect on reduction of the glucose increase and caused hypoglycemia via a significantly raised insulin secretion in the late phase.”
“The basal glucose uptake was increased 2.7-fold by gliclazide (p < 0.05).”
“One mu mol/1 of gliclazide in samples leads to an apparent loss of about 2.5 mu mol/l of glucose.”
“Under 5 mM glucose infusion , IRI and IRS were increased by gliclazide in a dose-dependent manner, but IRG was unchanged.”
“Both in the absence or presence of 5.6 mM glucose, gliclazide caused a rapid and sustained increase in [Ca2+]i.”
“In the presence of gliclazide (200 micrograms/ml) the translocation of glucose from the lumen to the blood was significantly reduced at the three arterial concentrations of glucose without affecting the intestinal absorption rate.”
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