supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Ghrelin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Acute ghrelin administration increases ACTH and cortisol concentrations and a feedback loop between the ghrelin and ACTH-cortisol axis has been postulated.”
Four-hour infusion of hydrocortisone does not suppress the nocturnal increase of circulating acyl- or desacyl-ghrelin concentrations in healthy young adults.“A significant increase in ∆ AUC ACTH (pg/ml.90 min) after ghrelin was observed in thyrotoxicosis (4,189 ± 1,202) compared to controls (1,499 ± 338).”
“ Ghrelin , the endogenous ligand for GHS-receptors (GHS-R), increases GH, ACTH , cortisol and glucose levels in humans.”
“In controls ACTH (pg/mL) release after ghrelin (79.2 ± 26.8) was higher than after GHRP-6 (23.6 ± 5.7).”
“AVP, ACTH and cortisol significantly rose in response to ghrelin injection; however, in all subjects the AVP rise preceded the ACTH/cortisol responses.”
“…,ghrelin stimulated an immediate increase in plasma levels of GH (area under the curve, mean±SEM 35±16 ng/ml × min ….001), cortisol (5908±984 ng/ml × min [P] to 10179±1293 ng/ml × min [G]; p<0.001), and ACTH (922±103 pg/ml × … leptin levels remained unchanged.”
“As expected, AG induced marked increase (p < 0.01) in circulating GH, PRL, ACTH and cortisol levels.”
“In OB, ghrelin increased (P < 0.01) GH, PRL, ACTH , and cortisol levels.”
“… acylated ghrelin induced prompt and marked increase in circulating GH levels (AUC: 5452.4±904.9 μg*… in PRL (1273.5±199.7 μg*min/l; p<0.01 vs placebo), ACTH (4482.7±954.4 pg*min/ml; p<0.… μg*min/l; p<0.01 vs placebo).”
“A reciprocal relationship has been reported between corticotropin-releasing hormone (CRH) and ghrelin as ghrelin increases the release of CRH, ACTH and corticosteroids; while CRH decreases the expression of ghrelin.”
“After 4 h of incubation with ghrelin , medium ACTH concentrations were two‐ to ten‐fold higher compared to ACTH concentrations in unstimulated wells.”
“ Ghrelin , like its synthetic counterparts, the growth hormone (GH) secretagogues, has been shown to markedly stimulate adrenocorticotrophic hormone (ACTH) and cortisol secretion in humans and the ACTH‐releasing effect of GH secretagogues is even greater in patients with pituitary ACTH‐secreting tumours.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback