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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Genistein
supplement:
Zinc Sulfate
Research Papers that Mention the Interaction
“Mineralisation was enhanced by coumestrol (10- 5 to 10- 7 m), daidzein (10- 5 to 10- 6 m) and genistein (10- 5 m); and Zn significantly augmented this response.”
Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiation in vitro.“Agarose gel electrophoresis showed the presence of low‐molecular weight deoxyribonucleic acid (DNA) fragments of adherent cells cultured with genistein (10−6 M) plus zinc (10−5 M) for 24 or 72 h, indicating that the combination of two chemicals induces apoptotic cell death.”
“Culture with genistein (10−6 M) plus zinc (10−5 M) for 72 h caused a significant increase in caspase‐3 mRNA expression in the presence or absence of M‐CSF and RANKL as compared with the value for each chemical alone.”
“This study demonstrates that the combination of genistein and zinc has potent stimulatory effects on apoptotic cell death and suppressive effects on osteoclastic cell function.”
Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling‐related gene expression in osteoclastic cells“The presence of zinc sulfate (10-5 M) caused a significant increase in the genistein (10-5 M)-elevated alkaline phosphatase activity, DNA and calcium contents.”
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