Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 6 months ago

Possible Interaction: Genistein and Tiazofurin

supplement:

Genistein

Research Papers that Mention the Interaction

Genistein acts synergistically with drugs such as tamoxifen, cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea (BCNU), dexamethasone, daunorubicin and tiazofurin , and with bioflavonoid food supplements such as quercetin, green-tea catechins and black-tea thearubigins.
Advances in experimental medicine and biology  •  2004  |  View Paper
Current studies reveal that tiazofurin with quercetin, tiazofurin with genistein , and quercetin with genistein were synergistic in killing human cancer cells and in reducing signal transduction activity.
Advances in enzyme regulation  •  1999  |  View Paper
Combinations of tiazofurin with quercetin, tiazofurin with genistein , and quercetin with genistein yielded a synergistic kill of ovarian cancer cells.
European journal of gynaecological oncology  •  2000  |  View Paper
Because genistein and tiazofurin attack different enzymic targets and arrest the cell cycle at different phases, we tested the hypothesis that tiazofurin might be synergistic with genistein.
However, genistein added 12 h after tiazofurin decreased cell counts to 8%, showing synergistic action of the two drugs for growth inhibition.
Tiazofurin (20 microM) and genistein (20 microM) as single agents reduced cell counts to 60% and 50%, respectively.
Oncology research  •  1998  |  View Paper
Since tiazofurin and genistein attack different enzymic targets and arrest the cell cycle at different phases and they each induce differentiation, we tested the hypothesis that tiazofurin might be synergistic with genistein in inducing differentiation.
Life sciences  •  1998  |  View Paper