Possible Interaction: Genistein and Tiazofurin

“ Genistein acts synergistically with drugs such as tamoxifen, cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea (BCNU), dexamethasone, daunorubicin and tiazofurin , and with bioflavonoid food supplements such as quercetin, green-tea catechins and black-tea thearubigins.”

“Current studies reveal that tiazofurin with quercetin, tiazofurin with genistein , and quercetin with genistein were synergistic in killing human cancer cells and in reducing signal transduction activity.”

“Combinations of tiazofurin with quercetin, tiazofurin with genistein , and quercetin with genistein yielded a synergistic kill of ovarian cancer cells.”

“Because genistein and tiazofurin attack different enzymic targets and arrest the cell cycle at different phases, we tested the hypothesis that tiazofurin might be synergistic with genistein.”

“However, genistein added 12 h after tiazofurin decreased cell counts to 8%, showing synergistic action of the two drugs for growth inhibition.”

“ Tiazofurin (20 microM) and genistein (20 microM) as single agents reduced cell counts to 60% and 50%, respectively.”

“Since tiazofurin and genistein attack different enzymic targets and arrest the cell cycle at different phases and they each induce differentiation, we tested the hypothesis that tiazofurin might be synergistic with genistein in inducing differentiation.”