Possible Interaction: Genistein and Resveratrol

“All three factors were significantly reduced in lymphocytes treated with resveratrol and genistein , and the inhibitory effects of resveratrol on NF-κB, TNF-α and MMP-9 were more potent than the effects of genistein.”

“Significantly elevated caspase-3 activity was noted after treatment with genistein (10−9–10−7 mol/l), as well as with resveratrol and quercetin (10−9–10−5 mol/l).”

“After 24 h of exposure to resveratrol and genistein , individually or in combination, lowered mitochondrial membrane potential was observed in HeLa cells.”

“Our findings suggest that resveratrol and genistein when combined can induce apoptosis at doses lower than usual doses, through the activation of caspases cascade, and by decreasing the expression of HDM2.”

“We also detected an obvious decrease in the level of HDM2 gene expression after both individual and combination treatments with resveratrol and genistein.”

“We conducted several experiments to test whether genistein can synergistically enhance the apoptotic potential of resveratrol at doses lower than the usual cytotoxic dose.”

“We further demonstrated that genistein decreased the dedifferention marker CD97 in NPA cells and resveratrol decreased CD97 in FTC-133, NPA, FRO cells and quercetin decreased CD97 in all cell lines.”

“While genistein , resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein.”

“We evaluated the potential additive and synergistic effects of genistein and resveratrol for suppressing prostate cancer in the Simian Virus‐40 T‐antigen (SV‐40 Tag) targeted probasin promoter rat model, a transgenic model of spontaneously developing prostate cancer.”

“The results demonstrate that GEN and RES have distinct inhibitory effects on vasoconstriction induced by O2*- generated by X/XO and H2O2, and their actions are clearly greater than to that of EST.”

“ Genistein failed to mimic the elevated iNOS activity induced by resveratrol.”

“Structural models showed that intercalation is more stable for resveratrol and genistein than groove bindings, while curcumin interaction is via DNA grooves.”

“Binary combinations of cranberry extract and resveratrol with genistein , protocatechuic or p-hydroxibenzoic acid enhanced the stimulatory effect on S. epidermidis biofilm formation and maintained or even increased S. aureus anti-biofilm activity.”