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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Genistein
drug:
Repaglinide
Research Papers that Mention the Interaction
“In conclusion, genistein inhibited the efflux of repaglinide mediated by P-gp in rats and in vitro.”
“The findings suggested that the DDI between genistein and repaglinide is mediated by P-gp, and a dosage adjustment may be needed when they are co-administered in a clinical setting.”
“The maximum plasma concentration (Cmax) of repaglinide increased from 70.80 ± 7.98 ng/mL to 124.71 ± 9.… 134.89 ± 13.65 μg·h/L to 245.95 ± 7.24 μg·h/L. Intestinal absorption of repaglinide … genistein or P-gp inhibitor verapamil (… everted rat intestinal sac preparations.”
“When genistein was added, the plasma concentrations of repaglinide in rats were increased.”
Molecular pharmacokinetic mechanism of the drug-drug interaction between genistein and repaglinide mediated by P-gp.
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