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Last Updated: 4 years ago

Possible Interaction: Genistein and Recombinant Human Chorionic Gonadotropin

supplement:

Genistein

drug:

Recombinant Human Chorionic Gonadotropin

Research Papers that Mention the Interaction

“With low concentrations of genistein and daidzein we observed a stimulation of the production of hCG and a weak inhibition of proliferation in both cell lines BeWo and Jeg3.”
Effects of phytoestrogens on the trophoblast tumour cell lines BeWo and Jeg3.
Anticancer research  •  2003  |  View Paper
“rIL-6- and rsIL-6R-induced hCG production was significantly blocked by anti-IL-6R antibody, PM1; antisignal transducing glycoprotein 130 (gp130) antibody, GPX7; or a tyrosine kinase inhibitor, genistein.”
Soluble interleukin-6 (IL-6) receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer.
The Journal of clinical endocrinology and metabolism  •  1995  |  View Paper
“Nonetheless, genistein did suppress the ex vivo steroidogenic response of Leydig cells to hCG or dibutyryl cAMP by down-regulating their expression of P450 scc.”
Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis.
The Journal of endocrinology  •  2005  |  View Paper