Possible Interaction: Genistein and Polypeptides

“ Genistein inhibits the activation of the kappa light polypeptide gene enhancer in B-cells (NF-κB), signaling pathway, which is implicated in the balance between cell survival and programmed cell death (apoptosis).”

“The conformational investigation showed that the presence of 0020 genisteins led to changes in the secondary structure of BSA and induced the slight unfolding of protein polypeptides , which confirmed some micro-environmental and conformational changes of BSA molecules.”

“In the presence of genistein , the phosphorylation of tyrosine residues in specific viral polypeptides was markedly reduced.”

“ Genistein , a phosphotyrosine kinase inhibitor, inhibited PRL-induced signal transducer and activator of transcription-5 activation and Na(+)/taurocholate-cotransporting polypeptide mRNA.”

“The results show that chronic treatment … neurons with tyrosine kinase inhibitor genistein ) resulted in downregulation … NR2B subunit polypeptide levels, while daidzein, an inactive analog of genistein, did not alter the levels of NR2B subunit, … that tyrosine kinases may be involved in the regulation of the NMDA NR2B subunit content.”

“ Genistein , a phosphotyrosine kinase inhibitor, inhibited PRL-induced signal transducer and activator of transcription-5 activation and Na+/taurocholate-cotransporting polypeptide mRNA.”