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Last Updated: 5 months ago

Possible Interaction: Genistein and Ng-Nitroarginine Methyl Ester

Research Papers that Mention the Interaction

Pretreatment with the nitric oxide synthase (NOS) inhibitor L-N-nitroarginine methyl ester L-NAME , 100 μmol/L) significantly inhibited the effects of GST, high magnesium, and the combination of GST and magnesium.
Canadian journal of physiology and pharmacology  •  2015  |  View Paper
Interestingly, the aforementioned effects of genistein were abolished by pretreatment with L-NAME , an inhibitor of eNOS activation.
Hippocampus  •  2013  |  View Paper
These beneficial effects of genistein were blocked by a nonselective NOS inhibitor ( L-NAME ), but not by a selective iNOS inhibitor (aminoguanidine).
Canadian journal of physiology and pharmacology  •  2012  |  View Paper
While a nitric oxide (NO) synthase (NOS) inhibitor, N(G)-nitro-l-arginine methyl ester (100 microM, 30 min) inhibited the relaxation, a PI3K/Akt inhibitor, LY294002 (10 microM, 30 min) or a tyrosine kinase inhibitor, genistein (30 microM, 30 min) was ineffective.
Biochemical and biophysical research communications  •  2010  |  View Paper
Both agents exhibited an antiaggregatory action, dependent on the nitric oxide release from vascular tissue, since preincubation of aortic strips with L-NAME partially and completely suppressed the inhibition of platelet aggregation induced by genistein or raloxifene respectively.
Molecular and Cellular Endocrinology  •  2007  |  View Paper
Concurrent treatment with the estrogen receptor (ER) antagonist ICI182,780 (10(-7) M) or the NOS inhibitor L-NAME (3 x 10(-3) M) diminished the Gen (10(-6) M)-mediated increase in NOS activity, NO production, and cGMP content.
Journal of cellular biochemistry  •  2005  |  View Paper
genistein (… L-NAME , or by sodium orthovanadate (50 microg/kg), a potent inhibitor of protein tyrosine phosphatase; (2) genistein also decreased the PP of renal vascular … of mesenteric vascular bed in a dose-dependent manner, an effect which was partially inhibited by sodium orthovanadate, but unaffected by L-NAME.
Sheng li xue bao : [Acta physiologica Sinica]  •  2003  |  View Paper
The nitric-oxide synthase inhibitor N(omega)-nitro-L-arginine (100 microM) completely blocked the genistein , daidzein, and 17beta-estradiol-induced restoration of the relaxation response to carbachol, whereas the estrogen receptor antagonist ICI 182,780 (10 microM) had no effect on the relaxation responses.
The Journal of pharmacology and experimental therapeutics  •  2001  |  View Paper