Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Genistein and Kaempferol

supplement:

Genistein

supplement:

Kaempferol

Research Papers that Mention the Interaction

Genistein is a potent inhibitor of tyrosine kinases and along with flavonoids such as kaempferol and apigenin is also an inhibitor of topoisomerases I and II, enzymes which are crucial to cellular proliferation.
European Urology  •  1999  |  View Paper
Interestingly, effects of the mixture of genistein and kaempferol were stronger than those revealed by any of these compounds used alone.
Scientific reports  •  2015  |  View Paper
On the other hand, while quercetin, daidzein and luteolin did not alter the activity of CDK1, kaempferol, apigenin and genistein inhibited this kinase by 50-70%.
Biochemical pharmacology  •  2001  |  View Paper
Luteolin concentration showed a significant negative correlation with genistein (r2 = −0.45*).
Journal of dietary supplements  •  2017  |  View Paper