Possible Interaction: Genistein and Interleukin-10

“… GEN down-regulated CD163 and … the levels of IL-10 , increased the levels of IL-12 and nitric oxide (NO) in the conditioned medium, and reduced the clonogenic and sphere-… CD44 in SKOV3 cells induced by co-culture of THP-1 macrophages and OCSLCs in a dose-dependent manner.”

“… genistein did not normalize but significantly suppressed the elevated serum concentrations of MCP-1/JE from 286 ± 30 ng/…/L and KC from 321 ± 21 ng/L to 232 ± 20 ng/L while increasing that of IL-10 from 35 ± 4 ng/L to … in db/db+G mice.”

“ IL-10 signaling was blocked by a variety of agents, including IL-10 receptor antibodies, alpha-toxin, and Genistein.”

“In contrast, basal IL-10 mRNA expression correlated negatively with apoptosis induction in response to genistein (P < 0.01).”

“The antiproliferative effects of genistein could be reversed by the addition of exogenous IL-10.”

“The activity of … the treatment with genistein , as evidenced by the inhibition of NF-κB-p65, phospho-NF-κB-p65, and phospo-IκB-α … of IκB-α and the messenger RNA (mRNA) expression of inflammatory cytokines (MCP1, TNFα, IL1β, IL4, IL10 ) mediated by NF-κB … phase of the infection.”

“However at higher concentrations (> 50 μM), …-10 and IFN-γ levels, whereas genistein reduced levels …, IL-4, IL-10 , IFN-γ mRNA and protein and these results suggest that the Nano-soy supplementation improved … SAMP8 mice which may be attributable to higher daidzin content in the black soybean preparation.”

“Two distinct tyrosine kinase inhibitors, herbimycin and genistein affected the expression of TNF-R in response to IL-10 but, surprisingly, with opposite effects.”

“ Genistein induced an increase in the activity of SOD and the level of IL-10 , while causing a decrease in NO, MDA, and TNF-α in injured spinal cord tissue.”

“ Genistein suppressed the production of IFN-γ and enhanced IL-10 secretion in splenocyte and brain.”