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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Genistein
drug:
Ici 182780
Research Papers that Mention the Interaction
“Estrogen receptor beta was expressed in the cultured cells, and genistein protection was blocked by ICI-182780 administration as well as Bcl-2 siRNA transfection.”
Mechanisms of genistein protection on pancreas cell damage in high glucose condition.“These actions of 17-epiestriol and genistein were significantly attenuated in the presence of the estrogen receptor antagonist ICI-182780.”
“The suppressive effects of genistein and PPT were inhibited by an additional treatment with ICI182780 (a nonselective ER antagonist) or 1,3-bis(4- hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride (MPP, a selective ERα antagonist).”
Genistein Suppressing the ROS-Induced Hypersensitivity of Rat Vagal Lung C-Fiber Afferents through an ERα-Mediated Mechanism.“An estrogen receptor antagonist, ICI182780 , reversed the effects of genistein , indicating that this effect of genistein is mediated through estrogen receptors.”
“In rat aortic strips, 10nM genistein or 10nM raloxifene significantly increased nitric oxide synthesis, event prevented by ICI182780.”
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