Possible Interaction: Genistein and Doxorubicin Hydrochloride

“ Genistein also shows synergistic behavior with well-known anticancer drugs, such as adriamycin , docetaxel, and tamoxifen, suggesting a potential role in combination therapy.”

“Altogether this study highlights the potential role of … in targeting HSPG receptors and synergistic delivery of Dox … Gen as a promising strategy to effectively inhibit BAC progression and these findings could open a new window to deliver combinations of chemotherapeutic agents along with anti-angiogenic ligands using hybrid nanoparticles.”

“Consistent with previous reports, genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells, and genistein reduced the chemoresistance of these cells.”

“ Genistein treatment increased the intracellular accumulation of doxorubicin but did not influence P-gp function.”

“The combination of genistein and doxorubicin significantly induced cell cycle arrest and apoptosis.”

“Therefore, our results demonstrated that genistein combined with doxorubicin had a synergistic effect on MCF-7/Adr cells, and the mechanisms likely involve an increase in the intracellular accumulation of doxorubicin and suppression of HER2/neu expression.”

“Collectively, our results clearly suggest that genistein pretreatment inactivates NF-kappaB and may contribute to increased growth inhibition and apoptosis induced by cisplatin, docetaxel, and doxorubicin in prostate, breast, lung, and pancreatic cancer cells.”

“ Genistein enhanced cytotoxic effect of ADR at low doses less than IC50 against the human breast cancer cell.”

“These results suggest that genistein enhances necrotic-like cell death of the breast cancer cells through the inactivation of HER-2 receptor and Akt in combination with ADR.”

“Combinations of genistein or tyrphostin AG 1478 with cisplatin, doxorubicin , or etoposide enhanced the antiproliferative effects and induced programmed cell death in NCI-H596 cells, whereas no such additive effects were observed in NCI-H358 cells.”

“The tyrosine kinase inhibitor genistein was a potent blocker of doxorubicin efflux in the PSN1/ADR cells but showed no activity in the H134 AD cells.”

“Although the amount of ADM was decreased in the nuclei of K562/TPA cells, it was significantly increased after incubation in the presence of genistein.”

“Three inhibitors of tyrosine kinases genistein , kaempferol, and quercetin) can inhibit the in vitro generation of ADR activity.”

“ Genistein enhanced the Nrf2 and HO-1 expression, which showed protection against oxidative insult induced by Dox.”