Possible Interaction: Genistein and Colforsin

“ Genistein at the smallest concentration (0.01 mM) augmented epinephrine-stimulated (1 microM) lipolysis but failed to potentiate lipolysis induced by forskolin (1 microM) or dibutyryl-cAMP (1 mM).”

“ Genistein increased the forskolin-induced macroscopic currents of wt-CFTR and delta F508-CFTR by 3- and 19-fold, respectively.”

“Stimulation of monolayers with forskolin significantly increased their sensitivity to flavonoids: kaempferol (2.5 +/- 0.7 microM) </= apigenin (3.4 +/- 0.9 microM) </= quercetin (4.1 +/- 0.7 microM) </= genistein (6.9 +/- 2.2 microM).”

“Pretreatment with genistein also abolished the increase in the Isc when induced by forskolin , IBMX or UTP.”

“However, genistein (17.5-35 microM) produced parallel, leftward shifts in the concentration-response curves of forskolin and nitroprusside and significantly increased the pD2 values of these two agonists.”

“In addition, forskolin had a reduced effect on I(sc) of the mouse jejunum in the presence of genistein.”

“In G551D-CFTR cells, channel activity was recovered by co-application of forskolin and genistein in a dose-dependent manner.”

“In wild-type CHO cells, after exposure to 2.5 mM forskolin , 25 mM genistein induced a further 2-fold and rapid increase of the forskolin-activated CFTR current.”

“However, genistein , a specific inhibitor of tyrosine kinase(s), significantly reduced the effect of serum on forskolin‐induced stellation.”

“The relaxation induced by forskolin , an activator of adenylyl cyclase, was potentiated by genistein or theophylline.”