Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Genistein and Calcium Supplement

supplement:

Genistein

Research Papers that Mention the Interaction

In oocytes, both wtCFTR and ΔF508‐CFTR were activated by genistein while both cyclic AMP (KvLQT1) and Ca2+ (SK4) activated K+ channels were inhibited at high concentrations of genistein.
British journal of pharmacology  •  2000  |  View Paper
The Ca2+ -induced karyophilicity is prevented by inhibitors of either tyrosine kinases (herbimycin A and genistein ) or tyrosine phosphatases (vanadate), suggesting the involvement of Ca2+-dependent phosphorylation/dephosphorylation events.
The Journal of Biological Chemistry  •  1997  |  View Paper
The tyrosine kinase inhibitor, genistein , blocked the transient increase in intracellular Ca and the oxidative burst induced by sulfatides, suggesting that this tyrosine phosphorylation is functionally important.
The Journal of Biological Chemistry  •  1995  |  View Paper
Genistein , at 52.85 mg/d, increased bone calcium retention by 3.4% (95% CI: 0.5%, 6.2%; P = 0.029); but there was no benefit at higher amounts (113.52 mg/d).
The American journal of clinical nutrition  •  2015  |  View Paper
Genistein at 0.5 mmol/L significantly inhibited bFGF induced changes of calcium.
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology  •  2004  |  View Paper
Genistein not only abrogated the IFN-gamma-induced enhancement of tyrosine phosphorylation, but also inhibited the IFN-gamma-induced production of inositol-4-5-triphosphate and the elevation of intracellular calcium.
Journal of immunology  •  1993  |  View Paper
Genistein can significantly modulate bone metabolism related gene expression level of rat femoral tissue in vitro, and can increase calcium content and the activity of ALP.
The results showed that 1 x 10(-5) mol x L(-1) genistein could increase the activity of ALP and contents of Ca , regulate bone metabolism activity of OPG, RANKL, BMP-2, Collagen-I and Runx-2 mRNA expression level.
Yao xue xue bao = Acta pharmaceutica Sinica  •  2013  |  View Paper
The results showed that pretreatment with genistein significantly increased cell viability and PKC activity, decreased the levels of intracellular calcium , attenuated Hoechst/PI staining and blocked caspase-3 activity in Aβ25–35-treated PC12 cells.
Neurochemical Research  •  2012  |  View Paper
Genistein (a tyrosine kinase inhibitor) slowed down the Ca <sup>2+</sup> undershoot drop and the SR-Ca<sup>2+</sup> load but did not affect the undershoot recovery rate.
Cellular Physiology and Biochemistry  •  2009  |  View Paper
Our results suggest that genistein counteracts the induction of a marker of colonic premalignancy by low nutritional calcium in both genders.
The Journal of nutrition  •  2007  |  View Paper
Show More