“ Genistein can significantly modulate bone metabolism related gene expression level of rat femoral tissue in vitro, and can increase calcium content and the activity of ALP.”
“The results showed that 1 x 10(-5) mol x L(-1) genistein could increase the activity of ALP and contents of Ca , regulate bone metabolism activity of OPG, RANKL, BMP-2, Collagen-I and Runx-2 mRNA expression level.”