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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Genistein
drug:
Becaplermin
Research Papers that Mention the Interaction
“The PDGF-BB mediated increase of adhesion was inhibited in the presence of genestein , a tyrosine-kinase inhibitor and by protein kinase C downregulation with phorbol 12-myristate 13-acetate.”
Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs.“Pretreatment of cells with genistein (0.37 microM), a specific tyrosine kinase inhibitor, attenuated the proliferative effect of IL-1 beta and PDGF-BB.”
“The mitogenic response occurring in the presence of PDGF-bb and high glucose was totally inhibited by the tyrosine kinase inhibitors (imatinib and genistein ) and could not be mimicked by increasing diacylglycerol in low glucose media with the diacylglycerol kinase inhibitor, R59949.”
High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-beta1.
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