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Last Updated: 3 years ago

Possible Interaction: Genistein and Apigenin

supplement:

Genistein

supplement:

Apigenin

Research Papers that Mention the Interaction

Genistein is a potent inhibitor of tyrosine kinases and along with flavonoids such as kaempferol and apigenin is also an inhibitor of topoisomerases I and II, enzymes which are crucial to cellular proliferation.
European Urology  •  1999  |  View Paper
Furthermore, the binding free energy of apigenin was lower than that of genistein.
Journal of biochemical and molecular toxicology  •  2010  |  View Paper
Genistein at 10–5 M was inhibitory, while apigenin significantly potentiated the response at 19–7 M. In contrast, DDT had no effect on the FSH-induced response, though 10–7 M octyl-phenol nearly doubled the response.
Experimental biology and medicine  •  2001  |  View Paper