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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Genistein
drug:
Aldesleukin
Research Papers that Mention the Interaction
“It was found that genistein inhibited CD69 antigen expression induced by rIL-2 and by rIL-12, but not that induced by rIFN-alpha.”
Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rIL-2, rIL-12, and rIFN-alpha in human NK cells.“ Genistein blocked the expression of IL-2 and IL-2R (CD25) in T cells stimulated with PHA/PMA or CD3 mAb/PMA, but did not inhibit the de novo expression of the CD69 early activation Ag, which is induced primarily by a PKC-dependent pathway.”
“At doses that inhibited TPK activity and tyrosine phosphorylation of the TCR zeta subunit, but not phospholipase C activity, genistein prevented TCR-CD3-mediated phospholipase C activation, interleukin-2 receptor expression, and T cell proliferation.”
“However at higher concentrations (> 50 μM), …-10 and IFN-γ levels, whereas genistein … IL-2 , IL-4, IL-10, IFN-γ mRNA and protein and these results suggest that the Nano-soy … response in SAMP8 mice which may be attributable to higher daidzin content in the black soybean preparation.”
Nanonized black soybean enhances immune response in senescence-accelerated mice“Rapid endocytosis of IL-2 was inhibited by the tyrosine kinase inhibitor genistein , implicating a role for a signal transduction pathway in IL-2 internalization.”
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