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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Gemcitabine
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“The most striking observation was the ability of sulforaphane to potentiate the activity of several classes of anticancer agents including paclitaxel, docetaxel, and gemcitabine through additive and synergistic effects.”
Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems“In addition, a combinational treatment of SFN and gemcitabine on MCF-7 cells resulted in growth inhibition in a synergistic manner with a combination index (CI) <1.”
“The combination of SFN and gemcitabine may potentiate the efficacy of gemcitabine and minimize the toxicity to normal cells.”
“Additionally, a combination of sulforaphane and gemcitabine was found to increase the growth inhibition in a synergistic manner in HeLa cells compared to the individual drugs.”
“Although cisplatin (CIS), gemcitabine GEM ), doxorubicin, 5-flurouracil, or SF effectively induced apoptosis and prevented viability, combination of a drug with SF increased toxicity.”
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.
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