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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Gemcitabine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ CA 19-9 decrease was greater with G+T340 versus gemcitabine (-5,398 v -549 U/mL, respectively; P = .008).”
Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer.“ GEM therapy reduced significantly the level of the CA 19-9 tumor marker, and diagnostic imaging allowed a judgment of partial response or stable disease after 18 months.”
“Both patients showed a significant elevation of pretreatment CA 19-9 levels (7,505 and 150,000 U/ml, respectively), however, subsequently they experienced a highly significant reduction (>90%) of CA 19-9 kinetics under gemcitabine chemotherapy.”
“ResultsPatients with advanced … adenocarcinoma receiving gemcitabine who experienced a decrease of ≥20% in CA 19-9 concentration had a median survival of 13.9+ months (range 4.2–23.5) compared to 7.6+ months (range 4.0–14.7) in those without such a change (p = 0.0109).”
“In conclusion, a decrease of CA 19–9 > 20% during the first weeks of chemotherapy with gemcitabine is associated with a better survival of patients with locally advanced or metastatic pancreatic cancer.”
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