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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gelatin
drug:
Collagenases
Research Papers that Mention the Interaction
“In addition, the gelatin effectively inhibited enzyme activities, that is, collagenase and proteolytic enzymes released from the exocrine tissue, and thus it can inhibit overdigestion of islets during their density gradient isolation.”
Gelatin density gradient for isolation of islets of Langerhans.“This purification scheme resulted in a 280-fold enrichment of an active gelatin and type IV collagen-degrading enzyme.”
“In contrast, pre-treatment of collagen and gelatin by collagenase resulted in a higher stimulatory capacity compared to non-digested proteins.”
Collagen regulates the activation of professional phagocytes of the teleost fish gilthead seabream.“The collagenase peak also degraded proteoglycan, gelatin , fibronectin, laminin, and azocoll.”
“This study describes a novel extraction method named collagenase-assisted extraction (CAE), which uses collagenase to degrade gelatin into fragments with reduced hydrophobicity, allowing gelatin-related peaks to elute immediately, eliminating interference with the drug peak and enabling use of whole gelatin capsules during drug quantification.”
A novel collagenase-assisted extraction of active pharmaceutical ingredients from gelatin products for quantitative analysis by high performance liquid chromatography.“All of the collagenases are 5-10 times more active against gelatin than collagen.”
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