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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Aged garlic extract significantly inhibited saquinavir efflux from rat hepatocytes, while the efflux of darunavir significantly increased.”
“All tested phytochemicals (except S-allyl L-cysteine) and aged garlic extract inhibited CYP3A4 metabolism of both drugs and modulated hepatic distribution of the corresponding saquinavir and darunavir metabolites.”
Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir.“Invitro studies reported that garlic extracts increased DRV Pglycoprotein-mediated efflux leading to a decrease in intracellular concentration of DRV in both enterocytes and hepatocytes [4, 5].”
“We report two cases of HIV-infected patients displaying clinically significant interactions between garlic and darunavir (DRV), which resulted in sub-therapeutic DRV plasma concentration associated with viral rebound.”
“Because of the observed in vitro interactions between aged garlic extract and HIV protease inhibitors ( darunavir , saquinavir), any alterations of in vivo liver transport in the presence of garlic phytochemicals could also significantly influence darunavir/saquinavir hepatocyte intracellular concentrations and hence their bioavailabilities.”
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