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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Tocopherol
supplement:
Vitamin E
Research Papers that Mention the Interaction
“Supplementation with alpha-tocopherol increased serum alpha-tocopherol levels, while producing a marked decrease in serum gamma-tocopherol.”
A European multicentre, placebo-controlled supplementation study with alpha-tocopherol, carotene-rich palm oil, lutein or lycopene: analysis of serum responses.“These data support the hypothesis that alpha-tocopherol modulates xenobiotic metabolism by increasing Cyp3a expression, gamma-CEHC formation, and the excretion of both gamma-tocopherol and gamma-CEHC.”
“Recent evidence indicates that gamma-tocopherol may be a more powerful chemopreventive than the alpha-tocopherol.”
“Furthermore, we assume that alpha-Toc may affect the metabolism of gamma-Toc to gamma-CEHC in the body.”
“Secondly, the use of alpha-tocopherol supplements significantly reduces serum gamma-tocopherol , and this may have important biological effects.”
“ AT supplementation significantly decreased GT levels.”
“Plasma AT and GT levels increased following supplementation with AT alone or GT alone or in combination.”
“BACKGROUND Gamma-tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances gamma-tocopherol turnover.”
“RESULTS Neutrophil alphaT and ga maT in creased (both P <0.001) with mix ed tocopherol su pplementation, whereas alphaT (P <0.001) increased and gammaT decreased (P <0.005) after alphaT supplementation.”
“Supplementation with alpha-tocopherol caused alpha-tocopherol levels to rise (13.2 +/- 3.7 to 27.3 +/- 14 mug/mL), but gamma-tocopherol levels to decrease (4.1 +/- 1.6 to 3.5 +/- 1.1 mug/mL).”
“Vitamin E in supplements is mostly alpha-tocopherol , which may block the antioxidant activity of gamma-tocopherol and have a pro-oxidant effect in vivo.”
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