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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Tocopherol and Lovastatin

Research Papers that Mention the Interaction

HT29 cells were treated with different doses of lovastatin and gamma-tocopherol for 48 and 72 h. Lovastatin and gamma-tocopherol in combination induced the release of cytochrome c, caspase 3 activation, and loss of mitochondrial membrane potential more significantly compared to their controls.
Our data showed that lovastatin plus gamma tocopherol potently induced mitochondrial membrane potential collapse, cytochrome c release along with caspase 3 activation that reveals the importance of targeting programmed cell death signaling at different points of its signaling pathway for cancer therapy.
Recently, we found that lovastatin , a HMG-CoA reductase inhibitor, and gamma-tocopherol , one of the significant types of vitamin E in diet, additively induced apoptosis in a colorectal carcinoma cell line.
Nutrition and cancer  •  2014  |  View Paper
Conclusions This study showed that lovastatin when combined with gamma tocopherol , could induce apoptosis in HT29 cells more potently than each agent alone, which uncovers the significance of targeting the proliferative signaling in different points of the pathway.
Jundishapur journal of natural pharmaceutical products  •  2012  |  View Paper