Possible Interaction: Gamma-Tocopherol and Lovastatin

“HT29 cells were treated with different doses of lovastatin and gamma-tocopherol for 48 and 72 h. Lovastatin and gamma-tocopherol in combination induced the release of cytochrome c, caspase 3 activation, and loss of mitochondrial membrane potential more significantly compared to their controls.”

“Our data showed that lovastatin plus gamma tocopherol potently induced mitochondrial membrane potential collapse, cytochrome c release along with caspase 3 activation that reveals the importance of targeting programmed cell death signaling at different points of its signaling pathway for cancer therapy.”

“Recently, we found that lovastatin , a HMG-CoA reductase inhibitor, and gamma-tocopherol , one of the significant types of vitamin E in diet, additively induced apoptosis in a colorectal carcinoma cell line.”

“Conclusions This study showed that lovastatin when combined with gamma tocopherol , could induce apoptosis in HT29 cells more potently than each agent alone, which uncovers the significance of targeting the proliferative signaling in different points of the pathway.”