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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Gamma-Linolenic Acid and Vinorelbine

Research Papers that Mention the Interaction

An in vitro study has shown that gamolenic acid (oil from the seeds of evening primrose and borage) potentiates the cytotoxicity of paclitaxel and vinorelbime in human breast cancer cell lines (Menendez et al, 2002).
British Journal of Cancer  •  2004  |  View Paper
Both methods showed an overall synergism between GLA and VNR in MCF-7 cells.
For comparison, the effects of … examined on VNR chemosensitivity: GLA was the … enhancing VNR activity, followed by docosahexaenoic acid (22 : 6n-3), eicosapentaenoic acid (20 : 5n-3) and α-linolenic acid (18 : …), whereas linoleic acid (18 : 2n-6) and arachidonic acid (20 : 4n-6) did not increase VNR chemosensitivity.
Under conditions inhibiting lipid peroxidation using Vitamin E (dl-α-tocopherol), the enhancing effect of GLA (an easily oxidizable UFA) on VNR activity was partially abolished.
We found that GLA enhanced in a dose-dependent manner the cell growth inhibitory activity of VNR on MCF-7 cells (up to 9-fold).
Breast Cancer Research and Treatment  •  2004  |  View Paper