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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Gamma-Linolenic Acid
supplement:
Linolenic Acid
Research Papers that Mention the Interaction
“The coexistence of GLA and LLA during their catabolism diminished the amounts of respective metabolite in Hep G2 cells.”
“The presence of GLA inhibited completely the formation of C20:4(n-3) from LLA.”
Metabolism of gamma-linolenic acid in primary cultures of rat hepatocytes and in Hep G2 cells.“Measurement of cell viability by MTT assay indicated a significant cellular toxicity after ALA and GLA exposures.”
“… ALA … GLA was FAS inhibitory in an additive manner, and this FAS repression was only partially reversible by vitamin E. In examining the molecular mechanisms underlying …-regulated kinase (MAPK ERK1/2) inhibitor U0126, phosphatidylinositol-3'-kinase (PI-3'K) blocker LY294002, and/or anti-HER-2/neu antibody trastuzumab.”
“The conversion of ALA to higher metabolites was greatly affected by GLA ; EPA had no effect on ALA conversion, while DHA significantly inhibited it.”
Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation.“However, alpha-linolenic acid and gamma-linolenic acid at the same concentration were lethal to the cells.”
“The inhibition of the metabolism of linolenic acid by linoleate, γ-linolenate and arachidonate was evidenced in all three lipid classes and in all tissues.”
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