Possible Interaction: Gamma-Linolenic Acid and Eicosatrienoic Acid

“Consumption of GLA (2g/day), in the absence of STA or EPA, increased DGLA content with a tendency to increase AA content in some fractions.”

“Exogenous supplementation of GLA during 3 months increases the plasma level of dihomo-gamma-linolenic acid (p < 0.002), and to a smaller degree, the level in erythrocyte membrane lipids.”

“In group 2, the intake of γ-linolenic acid resulted in a strong rise of γ-linolenic acid and dihomo-γ-linolenic acid concentrations in plasma lipids, cholesteryl esters, and erythrocyte membranes.”

“DGLA and AA were both released during stimulation, and the quantities of DGLA mobilized increased threefold after in vitro GLA supplementation.”

“We have found that administration of relatively small amounts of GLA , up to 360 mg/d, raises human blood levels of dihomogammalinolenic acid (DGLA) and arachidonic acid (AA).”

“The GLA diet resulted in increased dihomo-γ-linolenic acid ( DGLA ) and ARA as early as week 2, supporting a ∆5 desaturase.”

“Supplement of γ-linolenate resulted in a reduction of the ratio of arachidonate to homo-γ-linolenate in both the cholesterol-fed group and the control group, but the ratio was much lower in the former.”

“Biochemical analysis of spleen cell membrane fatty acids revealed significant increases in the eicosanoid precursor fatty acids dihomo‐γ‐linolenic acid and arachidonic acid in response to gamma‐linolenic acid feeding, indicating rapid metabolism to longer chain omega‐6 fatty acids.”

“Feeding of GLA and DGLA resulted in significant alterations in levels of these fatty acids in phospholipids of mammary tissue, thymus, colon, liver, stomach, and ovary.”

“Conclusions:Supplementation … with γ-linolenic acid had the following, effects: … γ-linolenic acid, dihomo-γ-linolenic acid , and bicyclo-prostaglandin E; b) increased the plasma ratio of dihomo-γ-linolenic acid to arachidonic … c) favorably reduced the ratio of thromboxane B2, to 6-keto-prostaglandin F1α in injured rats.”