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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Zopiclone
Research Papers that Mention the Interaction
“ Zopiclone is chemically unrelated to benzodiazepines, but has a similar effect of potentiating the function of γ-aminobutyric acid (GABA) at the GABAA receptor complex (Karle and Nielsen, 1998).”
Zopiclone dependence after insomnia related to torticollis.“Furthermore, zopiclone slightly but significantly decreased GABA content in the hippocampus, the decrease being blocked by coadministration of the benzodiazepine receptor antagonist Ro 15-1788.”
“Intraperitoneal administration of zopiclone reduced the GABA turnover rates in both the striatum and hippocampus, as estimated from the rate of GABA accumulation after inhibition of GABA transaminase by aminooxyacetic acid (AOAA).”
Modification of GABA turnover in the striatum and hippocampus of the rat after zopiclone“3 Diazepam, zopiclone and CL 218,872 concentration‐dependently and reversibly enhanced responses to GABA.”
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