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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Zonisamide
Research Papers that Mention the Interaction
“Supratherapeutic doses of AZM, CBZ, PHT, TPM, and ZNS decreased extracellular levels of GABA , NE, DA, and 5-HT, without affecting Glu levels.”
“Therapeutically relevant doses of AZM, CBZ, TPM, and ZNS increased hippocampal extracellular levels of GABA , NE, DA, and 5-HT, while PHT had no effect.”
Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin“Striatal perfusion of ZNS (100 and 1000 microM) decreased the extracellular levels of GABA in STN and glutamate in SNr, but decreased extracellular GABA level in GP without affecting GABA level in SNr.”
“The therapeutically relevant concentration of ZNS inhibited ryanodine-induced GABA and glutamate releases, and abolished the inflection point in concentration-response curve for ryanodine on neurotransmitter exocytosis.”
“ZNS increased basal GABA release concentration-dependently without affecting basal glutamate release; however, K(+)-evoked glutamate and GABA releases were reduced by ZNS concentration-dependently.”
“These data show that the molecular effect of ZNS , with up-regulation of EAAC-1 and decreased production of GABA transporters, should result in increased tissue and synaptic concentrations of GABA.”
“Displacement studies revealed an inhibitory effect of clonazepam and an enhancement effect of GABA on specific [3H]zonisamide binding.”
“Displacement studies revealed an inhibitory effect of clonazepam and an enhancement effect of GABA on specific [3H]zonisamide binding.”
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