supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Zolpidem
Research Papers that Mention the Interaction
“At the 3α1:2β3 receptor, clinically relevant concentrations of zolpidem enhanced GABA in a flumazenil-sensitive manner.”
“Unlike benzodiazepines, zolpidem modulates tonic GABA currents in the rat dorsal motor nucleus of the vagus, exhibits residual effects in mice lacking the benzodiazepine binding site, and improves speech, cognitive and motor function in human patients with severe brain injury.”
Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface“Pharmacotherapy with benzodiazepines (such as temazepam) and zolpidem (Ambien; Sanofi-Aventis), which act by modulating the receptor complex for GABA (γ-aminobutryic acid), the principal inhibitory neurotransmitter in the central nervous system, is also common, in particular for acute insomnia.”
“Full benzodiazepine agonists flunitrazepam (1 microM) and zolpidem (10 microM) significantly potentiated the response to 10 microM GABA by 124+/-15% (n=7) and 117+/-23% (n=3), respectively.”
“ Zolpidem is a positive modulator of γ-aminobutyric acid(A) (GABA(A)) receptors, and engenders sedative effects that may be explained in part by how it modulates intrinsic brain activity.”
“Furthermore, long-term exposure to zolpidem significantly decreased the ability of GABA to stimulate [3H]flunitrazepam binding.”
“ Zolpidem is a short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid by binding to benzodiazepine type 1 receptors.”
“ Zolpidem is a commonly prescribed nonbenzodiazepine hypnotic that potentiates c-aminobutyric acid , by binding to benzodiazepine type 1 (BZ1) receptor.”
“In both forms, zolpidem potentiated the response to GABA in a concentration-dependent manner.”
“AIMS Hypnotic zolpidem is a positive allosteric modulator of γ-aminobutyric acid (GABA) action, with preferential although not exclusive binding for α1 subunit-containing GABA(A) receptors.”
The effects of zolpidem treatment on GABA(A) receptors in cultured cerebellar granule cells: changes in functional coupling.“Conclusion:The present in vitro and in vivo findings that zolpidem significantly potentiated GABA currents and thus inhibited the activity of the SNr provide a rationale for further investigations into its potential in the treatment of basal ganglia disorders.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback