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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Zinc Cation
Research Papers that Mention the Interaction
“The divalent cation Zn2+ , abundant in the CNS and retina, was found to inhibit GABA rho 1 receptors in a voltage-independent manner.”
A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors“In AT rat cerebellum, the effect of GABA was strongly inhibited by Zn2+ (IC50 < or = 1 microM), whereas in ANT rats, the divalent cation was about 100-fold less potent.”
Differential effects of zinc on native GABAA receptor function in rat hippocampus and cerebellum“Acute ethanol (100 mM) consistently inhibited 3 microM GABA currents (10-20%); positive modulators, pentobarbital (10 microM), midazolam (1 microM) and loreclezole (10 microM), consistently potentiated; the negative modulator, Zn2+ (30 microM), inhibited GABA currents across both juvenile and young adult groups.”
“ Zn2+ (2-100 microM) inhibited IGABA (limited to approximately 20% decrease) in a noncompetitive manner.”
“In both preparations, the concentration-response curves were biphasic, with 25% of the cerebellar and 20% of the cortical Cl- flux … 45% of the cerebellar and 50% of the cortical flux being blocked by concentrations of Zn2+ exceeding 10 microM. Zn2+ (100 microM) did not … by 100 microM GABA ….”
“Other divalent cations tested Zn2+ , Hg2+, Co2+, and Ni2+) were poor protectors, even when combined with GABA.”
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