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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Verapamil

Research Papers that Mention the Interaction

Pharmacological activation of L-type voltage-operated calcium channels with BayK 8644 produced a decrease in [cAMP]i similar to that induced by GABA, while blocking these calcium channels with verapamil reversed the effect of GABA on cAMP synthesis.
Neuroendocrinology  •  2007  |  View Paper
Verapamil can inhibit fertilization in vitro through regulating Myb expression of sperm, while GABA , dbcAMP and Verapamil may affect the process of fertilization through the way other than Myb expression.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology  •  2005  |  View Paper
The [Ca(2+)](i) rise due to GABA was suppressed in the absence of extracellular Ca(2+) or in the presence of the L-type voltage-gated Ca(2+) channel blocker, verapamil , suggesting that Ca(2+) may be entered through L-type Ca(2+) channels.
Neuroscience Research  •  2004  |  View Paper
Diltiazem, verapamil and methoxyverapamil (D 600) inhibited K+-evoked (30 mM) GABA release at very high concentrations (> 1 μM).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The voltage-dependent Ca2+ entry due to K+ depolarization, after maximal Ca2+ loading of the synaptosomes by Na+/Ca2+ exchange, and the consequent [3H]GABA release could be blocked by 50 μM verapamil.
Pflügers Archiv  •  2004  |  View Paper
On the basis of these results we conclude that amiloride and verapamil inhibit high K+-induced release of [3H]GABA by antagonizing the entrance of Ca2+ (and possibly Na+ when external Ca2+ is absent) through a population of voltage sensitive presynaptic Ca2+ channels activated by depolarization.
Neurochemical Research  •  2004  |  View Paper
It is concluded that in addition … the Ca2+ antagonistic properties of verapamil on the Ca2+‐dependent, depolarization‐… release of some neurotransmitters [ gamma aminobutyric acid (GABA and NE)], another mechanism probably mediated by presynaptic receptors underlies the effects of verapamil on DA and 5‐HT release from discrete brain regions.
Journal of neuroscience research  •  1995  |  View Paper
The ability of progesterone, GABA , or muscimol to stimulate exocytosis was blocked by the Ca2+ channel antagonists verapamil or nifedipine.
Biology of reproduction  •  1995  |  View Paper
In addition, GABA evoked an increase in [Ca2+]n measured by indo-1 fluorometry, which was depressed in the presence of verapamil or picrotoxin.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1995  |  View Paper
The GABA or muscimol effect on [Ca2+]i was antagonized by nifedipine (10 microM) or verapamil (50 microM), and completely abolished in the presence of 4 mM EGTA (low-calcium medium).
Neuroendocrinology  •  1993  |  View Paper
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