Possible Interaction: Gamma-Aminobutyric Acid and Urethane

“ Urethane potentiated the functions of neuronal nicotinic acetylcholine, & ggr;-aminobutyric acidA , and glycine receptors, and it inhibited N-methyl-d-aspartate and &agr;-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors in a concentration-dependent manner.”

“In picrotoxin pretreated animals anaesthetized with urethane, GABA produced an initial depression of cardiovascular parameters followed by an excitatory phase.”

“Infusion of 100 micrograms GABA into conscious rats reduced lordotic responsiveness within 15 min after injection; with a similar time course, the same dose markedly reduced MUSA in urethane anesthetized rats.”

“Intravenous GABA inhibited, in a bicuculline‐sensitive manner, contractions of the urinary bladder induced by preganglionic nerve stimulation in urethane anaesthetized rats, while it had no significant effect on contractions produced by postganglionic nerve stimulation.”

“Both GABA and muscimol, a powerful agonist at GABA receptors6, inhibited PRL secretion when injected into urethane anaesthetised female7 or freely moving male rats8.”

“When birds were anesthetized with urethane , which antagonizes GABAergic ( γ-aminobutyric acid ) transmission, HVC neurons were excited rather than inhibited, suggesting a role for GABA in the coordination of duet singing.”