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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Triiodothyronine
Research Papers that Mention the Interaction
“ GABA supplementation also significantly elevated the triiodothyronine (T3) hormone level and hemoglobin levels and decreased the heterophil–lymphocyte ratio (H/L ratio) (p <.0001).”
Alleviation by gamma amino butyric acid supplementation of chronic heat stress-induced degenerative changes in jejunum in commercial broiler chickens“Tonic currents evoked by low GABA concentrations were also reduced by T3 (40±5%, n=14), but not by T4.”
“We have previously shown that triiodothyronine (T3) inhibits gamma-aminobutyric acid type A (GABA(A)) receptors in synaptoneurosomes and transfected cells.”
“Studies of the effects of thyroid hormones on the uptake of neurotransmitters by homogenates of rat cerebral cortex have revealed a significant competitive inhibition of neuronal uptake of [3H]GABA by thyroid hormones ( T3 greater than T4 greater than rT3).”
“The IC50 for inhibition of GABA uptake by T3 was estimated at 4 microM and that of T4 at 11 microns.”
“Specific (per mg protein) activity … glutamic acid decarboxylase and of GABA uptake into neurons was reduced by the more physiologic (50 or 500 ng/ml) concentrations of T3 , probably due to a non‐neuronal increase in overall protein synthesis, since the total per culture values seem unaffected by hormone.”
Effects of triiodothyronine (T3) on the development of rat cerebellar cells in culture
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