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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Trifluoperazine
Research Papers that Mention the Interaction
“At 100 microM, GABA responses desensitized with a time constant near 27 s. Coapplication of TFP did not alter the lack of desensitization to 10 microM GABA but revealed a second, faster component (time constant approximately 0.7 s) to the attenuation at 100 microM GABA.”
“Single-channel recording from isolated outside-out membrane patches showed GABA-gated chloride events with a primary conductance of … and a minor component (representing less than 5% of all events) of 10 pS. With simultaneous application of GABA … TFP , event amplitudes remained unchanged but … frequency of opening was decreased.”
“ TFP , at 100 microM, attenuated responses to (% of control): GABA (7.5 +/- 2.3), glycine (15.4 +/- 5.5), and glutamate (64.5 +/- 5.5).”
Trifluoperazine blocks GABA-gated chloride currents in cultured chick spinal cord neurons.“ TFP also decreased the depolarization-induced, calcium-dependent release of [3H]GABA and this effect was unrelated to the calcium-flux across the plasma membrane since TFP also inhibited the release of GABA elicited by the calcium-ionophore A23187.”
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