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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Trazodone
Research Papers that Mention the Interaction
“In cortical slices, TRZ exerted a biphasic effect on GABA release.”
“…,TRZ antagonized dose-dependently, at concentrations from 10(-…) to 10(-6) M, the increase in GABA release induced by (+/-)DOI, a 5-HT(2A/2C) agonist, and the alpha receptor agonist phenylephrine, both …(-6) M. The pIC50 values were 8.31+/-0.24, and 5.99+/-0.52, respectively.”
A cortical GABA–5HT interaction in the mechanism of action of the antidepressant trazodone
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