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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Tranexamic Acid
Research Papers that Mention the Interaction
“Background We recently reported that tranexamic acid TXA ) evokes pain in rats by inhibiting γ-aminobutyric acid and glycine receptors on neurons in the spinal dorsal horn.”
Administration of tranexamic acid to patients undergoing surgery for adolescent idiopathic scoliosis evokes pain and increases the infusion rate of remifentanil during the surgery“… TXA … γ-aminobutyric acid neurotransmission and inhibits neural glycine receptors.6,7 When one examines the chemical structures of TXA, γ-aminobutyric acid, and glycine and their … agent, has not been reported to produce seizures.5 Lecker et al.1 report that high concentrations of TXA inhibit NMDA receptors.”
“However, a serious adverse effect of TXA is seizure due to inhibition of γ-aminobutyric acid ( GABA ) and glycine receptors in cortical neurons.”
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn“ TXA enhances neuronal excitation by antagonizing inhibitory γ-aminobutyric acid type A and glycine receptors.”
Ventriculolumbar perfusion and inhalational anesthesia with sevoflurane in an accidental intrathecal injection of tranexamic acid: unreported treatment options
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