Possible Interaction: Gamma-Aminobutyric Acid and Tramiprosate

“In this study, we show that homotaurine inhibits in vitro T cell proliferation to a similar degree as GABA but at lower concentrations.”

“In contrast to taurine, co-application of GABA with hypotaurine or homotaurine revealed that the dual effect is present separately for each compound: hypotaurine modulates positively the GABA current, while homotaurine shows a negative modulation, both in a dose-dependent manner.”

“In silico” modeling confirms these observations, but it also shows a second binding site for homotaurine , which could explain the negative effect of this compound on the current generated by GABA or hypotaurine, during co-application protocols.”

“Thus, these results strongly suggest a competitive interaction between GABA and homotaurine or hypotaurine for the same binding site. “”

“Taurine efflux was facilitated by exogenous taurine, hypotaurine, β-alanine and GABA, whereas GABA, nipecotic acid and homotaurine effectively enhanced GABA release.”

“Cross desensitization only occurred between GABA and homotaurine.”

“3 The selective GABAA receptor agonists, muscimol and homotaurine mimicked the positive inotropic effect of GABA while baclofen, the selective GABAB receptor agonist, did not.”

“ 3-Amino-1-propanesulfonic acid , but not glycine, taurine or beta-alanine, mimicked the effect of GABA on the ulceration, which was inhibited by picrotoxin.”

“The GABAA-receptor antagonists, bicuculline and picrotoxin, did not affect the GABA action whereas the GABAB-receptor antagonist, homotaurine , significantly inhibited the GABA effect.”

“A cross desensitization could be observed between the effects of muscimol or homotaurine on one hand and GABA on the other, but not between (+/-)-baclofen and GABA.”

“The GABAA receptor agonists, muscimol (0.3 mM) and homotaurine (1 mM), produced a slight inhibition of contractions and reduced the effects of a subsequent challenge with GABA.”

“The selective GABAB antagonists 5-aminovaleric acid (1 mM) and homotaurine (100 microM) completely suppressed the inhibitory effect of GABA on field stimulation-induced vasoconstrictions.”

“Muscimol and 3-amino-1-propanesulfonic acid , but not baclofen or glycine, mimicked the depolarization and conductance increase produced by gamma-aminobutyric acid on the melanotrophs.”