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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Topiramate
Research Papers that Mention the Interaction
“Testing the hypothesis of Ketter et al. (1999) the deactivating effects of TPM may be coupled to a predominance of potentiation of GABA , but the oversimplified basis of the model needs to be acknowledged.”
Ketter’s hypothesis of the mood effects of antiepileptic drugs coupled to the mechanism of action of topiramate and levetiracetam“With long-term dosing and once target doses were achieved at 4 weeks, significant elevations in GABA were observed compared with baseline for all three drugs ( topiramate 46%, gabapentin 25%, lamotrigine 25%).”
“This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.”
“ TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors).”
“ Topiramate is a GABAmodulating agent that enhances the effects of GABA mediated neurotransmission through GABAA receptors and has been shown to be effective in the treatment of Tourette syndrome.”
“In addition, topiramate increases GABA activity at its neuroreceptors, and an additional pharmacodynamic interaction must therefore also be considered.”
“The exact mechanism of action is unknown, … thatmay contribute to the efficacy of TPM include blockage of voltage-… channels, augmentation of γ-aminobutyric acid activity at some subtypes of the GABA-A receptors, antagonism of the AMPA/… subtype of the glutamate receptor, and inhibition of the carbonic anhydrase enzymes.”
“…,topiramate … GABA levels, as measured using proton magnetic resonance spectroscopy (MRS).ObjectivesThe purpose of this study was to measure the effect of acute oral topiramate on … men at three times: at baseline and 2 and 6 h after ingesting 50 (N=5) or 100 mg (N=5) of topiramate.”
“ Topiramate , a newer anticonvulsant, has a modulating effect on voltage-dependent sodium and calcium ion channels, potentiates GABA neurotransmitters and blocks kainite/AMPA glutamate receptors.”
“Valproate, topiramate , and gabapentin are likely to affect nociception by modulating gamma‐aminobutyric acid‐ (GABA‐) and/or glutamate‐mediated neurotransmission.”
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