Possible Interaction: Gamma-Aminobutyric Acid and Thyrotropin-Releasing Hormone

“Together, our data suggest that TRH inhibits MCH neurons by increasing synaptic inhibition from local GABA neurons.”

“A hypothesis that the analeptic effects of TRH may be mediated via an inhibition of GABA systems is discussed.”

“Potential interaction between gamma-amino butyric acid (GABA) and thyrotropin-releasing hormone (TRH) in eliciting a variety of central nervous system (CNS)-related biologic activities is well known; however, the mechanism underlying this interaction is not clearly defined.”

“The results of these studies show that TRH may facilitate GABA action by augmenting chloride ion influx and hyperpolarization of cerebellar neurons.”

“The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA , but not with bicuculline.”

“It is suggested that beta-Ala and GABA act at the pituitary by impairing the TSH response to TRH.”

“Response to thyrotrophin-releasing hormone (TRH) after 15 min of drug administration was blunted in GABA injected animals, as compared to saline-injected controls.”

“When TRH was injected at the same time as GABA and beta-Ala, the response was significantly lower than in controls.”

“The respiratory stimulant effect of TRH could be potentiated by pretreatment with naloxone, methylatropine or a low dose of GABA.”

“On the other hand, infusion of dopamine (10(-9) - 10(-6)M) and GABA (10(-8) - 10(-4)M) suppressed not only the basal PRL release from dispersed pituitary cells but also the PRL response to TRH and VIP.”

“ TRH and GABA , independently or via interaction between them, may play a reciprocal regulatory role in the activity of the mesolimbic DA system.”