Possible Interaction: Gamma-Aminobutyric Acid and Threonine

“During treatment, an increase in the extracellular amino acids alanine, glycine, glutamate, aspartate, serine, threonine , and taurine was found demonstrating a significant influence on the intracellular pool of free amino acids induced by DAB.”

“Dietary threonine reduced GABA levels, weakened metabotropic GABA responses in R2 neurons, and ameliorated memory deficits in plasticity mutants.”

“5) Large doses of γ-amino-β-hydroxybutyric acid inhibited the metabolic degradation and the rate of excretion of exogenous GABA.”

“Moreover, γ-amino-β-hydroxybutyric acid caused a statistically significant inhibition of GABA uptake by brain. (”

“ GABA enhanced the accumulation of amino acids (GABA, glycine, valine, proline, 5-oxoproline, serine, threonine , aspartic acid and glutamic acid) and organic acids (malic acid, lactic acid, gluconic acid, malonic acid and ribonic acid).”

“Metabolic profiling found … exogenous application of GABA led to increases in accumulations of … acids (glutamic acid, aspartic acid, alanine, threonine , serine, and valine), organic acids (aconitic acid, malic acid, succinic acid, oxalic acid, and threonic …), sugars (sucrose, fructose, glucose, galactose, and maltose), and sugar alcohols (mannitol and myo-inositol).”