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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Thiocolchicoside
Research Papers that Mention the Interaction
“Consistent with previous observations, thiocolchicoside also inhibited the binding of GABA to rat cerebral cortical membranes.”
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes.“ Thiocolchicoside , a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-aminobutyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptors.”
Characterization of [3H]thiocolchicoside binding sites in rat spinal cord and cerebral cortex.
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