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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Tetrodotoxin

Research Papers that Mention the Interaction

Basal GABA outflow in slices, but not in synaptosomes, appeared to be largely dependent upon neuronal activity, being prevented by tetrodotoxin (TTX).
Brain research  •  1993  |  View Paper
Chronic suppression of activity by the application of tetrodotoxin (TTX) reduced mIPSC amplitudes and the levels of GAD67 and GABA.
The Journal of Neuroscience  •  2012  |  View Paper
Tetrodotoxin reduced both pallidal and nigral GABA release without changing GLU levels.
Journal of neurochemistry  •  2007  |  View Paper
Tetrodotoxin inhibited both Ca2+-independent and Ca2+-dependent 4AP-evoked glutamate and GABA release equipotently, consistent with Na+ channel involvement.
Journal of Pharmacology and Experimental Therapeutics  •  2006  |  View Paper
Tetrodotoxin (TTX) 6×10−7M, a concentration known to block neuronal mechanism but not to modify muscle membrane and anaphylactic histamine release, strongly prevented the inhibition caused by GABA in the Schultz-Dale reaction and in anaphylactic histamine release.
Agents and Actions  •  2005  |  View Paper
Tetrodotoxin (TTX) (5×10−7mol/l) blocked the facilitation of spontaneous ACh release by GABA only when the slices were perfused with normal Krebs solution, but not when perfused with a KCl-enriched medium.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
TTX reduced basal monoamine and GABA releases without affecting glutamate release, whereas BFA did not affect them.
Journal of pharmacological sciences  •  2004  |  View Paper
Tetrodotoxin , which blocks sodium spiking in amacrine cells, and picrotoxin, which blocks the inhibitory action of GABA , only slightly reduced the surround.
The Journal of Neuroscience  •  2004  |  View Paper
In all cases, these responses were reduced by removing calcium from the saline and surangin B-evoked release of GLU, GABA , aspartic acid (ASP) and alanine was significantly inhibited by the sodium channel blocker tetrodotoxin.
Toxicon : official journal of the International Society on Toxinology  •  2003  |  View Paper
In contrast, intra-mPfc TTX decreased local GABA (-33+6%) while VTA GABA levels were not affected.
Journal of Neuroscience Methods  •  2002  |  View Paper
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