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“ Basal GABA outflow in slices, but not in synaptosomes, appeared to be largely dependent upon neuronal activity, being prevented by tetrodotoxin (TTX).”
“ Tetrodotoxin inhibited both Ca2+-independent and Ca2+-dependent 4AP-evoked glutamate and GABA release equipotently, consistent with Na+ channel involvement.”
Journal of Pharmacology and Experimental Therapeutics • 2006 | View Paper
“ Tetrodotoxin (TTX) 6×10−7M, a concentration known to block neuronal mechanism but not to modify muscle membrane and anaphylactic histamine release, strongly prevented the inhibition caused by GABA in the Schultz-Dale reaction and in anaphylactic histamine release.”
“ Tetrodotoxin (TTX) (5×10−7mol/l) blocked the facilitation of spontaneous ACh release by GABA only when the slices were perfused with normal Krebs solution, but not when perfused with a KCl-enriched medium.”
Journal of pharmacological sciences • 2004 | View Paper
“ Tetrodotoxin , which blocks sodium spiking in amacrine cells, and picrotoxin, which blocks the inhibitory action of GABA , only slightly reduced the surround.”
“In all cases, these responses were reduced by removing calcium from the saline and surangin B-evoked release of GLU, GABA , aspartic acid (ASP) and alanine was significantly inhibited by the sodium channel blocker tetrodotoxin.”