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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Substance P
Research Papers that Mention the Interaction
“We have earlier reported that substance P (SP), a peptide which is colocalized with GABA in these neurons, depresses excitatory synaptic transmission in this nucleus (Kombian, S.B., Ananthalakshmi, K.V.V., Parvathy, S.S. & Matowe, W.C. (2003) J. Neurophysiol.,”
Dopamine and adenosine mediate substance P‐induced depression of evoked IPSCs in the rat nucleus accumbens in vitro“… GABA … substance P revealed that approximately 40% of the GABA-IR neurons in the inner submucous plexus of the ileum also stained for substance P. Our … porcine enteric nervous system, GABA-containing neurons are primarily involved in the modulation of secretory processes rather than in the modulation of peristalsis.”
“Baclofen and GABA inhibit SP release from the primary afferent terminals by activating GABAB receptors.”
“Plasma content of SP and CGRP in the GABA treatment group was significantly lower than the control group (SP: 57±15 pg/mL vs 127±12 pg/mL; CGRP: 23±10 pg/mL vs 42±8 pg/mL) after remission (P<0.01).”
“ SP might regulate the excitability of peripheral nociceptors through inhibition of the “pre-synaptic inhibition” evoked by GABA , which may explain its role in pain and neurogenic inflammation.”
PKCɛ mediates substance P inhibition of GABAA receptors-mediated current in rat dorsal root ganglion“In in vitro brain slice experiments, in the presence of GABA , 1&mgr;mol/L SP increased action current frequency by a factor of 2.7±0.6 (n=5, P≤0.05, ANOVA).”
“Intranigral injections of GABA or dynorphin A inhibited, while intranigral injections of substance P or neurokinin A stimulated dopamine levels in the ipsilateral striatum.”
“Intracellular application of H7, a potent inhibitor of PKC, abolished inhibition of IGABA by SP, suggesting that the inhibition of IGABA by SP may be a result of intracellular phosphorylation of the GABAA receptor.”
“When the neurons were treated with SP prior to application of GABA , the GABA-activated current (IGABA) was inhibited markedly, which was concentration-dependent and could be blocked by spantide, an NK1 receptor antagonist.”
“With 10(-8), 10(-7), 10(-6) and 10(-5) mol/L SP, IGABA was inhibited by 18%, 24.8%, 25.9% and 28% respectively.”
“ Substance P (10 nM-1 microM) depressed the inward current produced by GABA (GABA current) in a concentration-dependent manner.”
“ Substance P (10 microM) evoked a significant increase in the release of aspartate, glutamate, GABA , glycine and taurine.”
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