Possible Interaction: Gamma-Aminobutyric Acid and Spermine

“Low concentrations of PhTX-343 and spermine also potentiated the responses to nicotine and gamma-aminobutyric acid.”

“In addition spermine caused a significant increase in GABA content in diencephalon and brainstem, 30 min after administration.”

“The present results demonstrate that spermine has the capacity to affect GABA metabolism and are in favor of the suggestion that endogenous polyamines may modulate GABAergic mechanisms.”

“ GABA and SPER significantly prolonged the vase life and prevented degradation of proteins and chilling damage and increased capacity of detoxifying and scavenging of H2O2 and reactive oxygen species (ROS), led to alleviate the negative consequences of the senescence and CI.”

“A review of … literature suggests that spermine could contribute to prey hypotension and paralysis by interacting with N-methyl-d-aspartate (NMDA) and …-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, nicotinic and muscarinic acetylcholine receptors, γ-Aminobutyric acid (GABA) receptors, blood platelets, … receptors, and Ca2+-ATPase.”

“Exogenous GABA also significantly reduced the accumulation of free putrescine (Put) and increased the levels of free spermidine (Spd) and spermine (Spm) in leaves, which improved the capacity for polyamine biosynthesis.”

“Hypoxia + GABA treatment significantly increased concentrations of free putrescine (Put), spermidine (Spd) and spermine (Spm) from day two to eight, promoting the PA conversion to soluble conjugated and insoluble bound forms.”