Possible Interaction: Gamma-Aminobutyric Acid and Sodium Chloride

“Moreover, the enhancing effect of GABA on [3H]ACh release was clearly Na+-dependent and was reduced by almost 90% in presence of 23 mM NaCl.”

“The extracellular levels of glutamate, taurine, and GABA were concentration-dependently reduced by excess NaCl ; high-affinity glutamate uptake increased.”

“The release of GABA was calcium-independent, but could be completely prevented by the substitution of sodium chloride by lithium or choline chloride in the extracellular medium, suggesting that GABA release could be triggered by multiple mechanisms that led to the flux of sodium into these cells.”

“An inwardly directed NaCl gradient stimulated GABA uptake markedly, and the time course of uptake exhibited an overshoot phenomenon indicating the presence of an active transport mechanism for GABA in these membranes.”

“ Sodium chloride clearly facilitated the potentiating effect of muscimol on [3H] flunitrazepam binding but produced a complex interaction with the effects of GABA itself and the partial agonist imidazoleacetic acid in the phosphate buffer system used.”

“ GABA and pentobarbital both enhanced this effect of NaCl.”

“This effect of NaCl was potentiated by GABA and pentobarbital.”

“ Sodium chloride itself increased benzodiazepine binding and also markedly enhanced the facilitation caused by GABA , by a further increase in the affinity of the benzodiazepine receptor.”

“Low concentration of NaCl not only promoted growth, but also stimulated endogenous GABA metabolism to affect key enzymes activities and mRNA levels for phenolics synthesis in barley seedlings.”

“ GABA reduced the oxidative damage in soybean sprouts caused by NaCl stress and enhanced the content of total phenolics, phenolic acids, and isoflavones by 16.58%, 22.47%, and 3.75%, respectively.”

“Enhanced activities of GABA synthesizing enzymes along with a decline in the activities of GABA degrading enzymes under NaCl exposure led to GABA accumulation in both the cultivars.”