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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Sitagliptin
Research Papers that Mention the Interaction
“Our study indicates that combined use of GABA and Sita produced greater therapeutic benefits, which are likely due to an enhancement of β-cell proliferation and a decrease in apoptosis.”
“We previously demonstrated that GABA and sitagliptin ( Sita ), a dipeptidyl peptidase-4 inhibitor which increases endogenous GLP-1 levels, mediated a synergistic β-cell protective effect in mice islets.”
Combined use of GABA and sitagliptin promotes human β-cell proliferation and reduces apoptosis.“We found that GABA and Sitagliptin possess additive effect on pancreatic β-cells, prompted us to ask the existence of common or unique targets of GLP-1 and GABA in pancreatic β-cells.”
“Recently, we reported that the combination of GABA and sitagliptin (a dipeptidyl peptidase‐4 inhibitor that increases endogenous GLP‐1) was more effective than either agent alone in reducing drug‐induced β‐cell damage and promoting β‐cell regeneration in mice.”
“Importantly, combined use of GABA and sitagliptin significantly enhanced these effects as compared with each of the monotherapies.”
Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice
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