Possible Interaction: Gamma-Aminobutyric Acid and Serotonin

“Modulation of 5-HT neurons in the dorsalraphe nucleus by GABA , glutamate and CRF profoundly regulate aggressive behaviors.”

“Schild plot analyses of the inhibitory actions of dopamine and serotonin on currents elicited by GABA showed slopes of 2.7 ± 0.3 and 6.1 ± 1.8, respectively, indicating a noncompetitive mechanism of inhibition.”

“More recently it has been shown that some neurons contain more than one classical transmitter, e.g. 5-HT plus GABA , further underlining the view that transfer of information across synapses may be more compex than perhaps hitherto assumed.”

“Furthermore, endogenous noradrenaline and GABA tonically regulate the extracellular concentration of 5-HT although the degree of tonicity appears to depend upon the sleep/wake cycle and the behavioral state of the animal.”

“… GABA has an inhibitory effect … as norepinephrine and serotonin and this inhibition may be involved in local circuits and interneurons, it has been suggested that the hypothesis of a … does not compete with but complements the well-established hypotheses of alterations in noradrenergic and serotonergic function in mood disorders.”

“Since 5-HT and GABA seem to function antagonistically in anxiety disorders their neocortical interaction may be (patho)physiologically relevant.”

“Thus, we propose that 5-HT2C receptors inhibit GABAA receptors by a Ca(2+)-dependent, but phosphorylation independent, mechanism and that 5-HT and GABA may act as cotransmitters to regulate neuronal activity.”

“Thus serotonin and acetylcholine stimulate and GABA inhibits the reorientation process.”

“There is evidence that neurotransmitters function in mouse palate development: Serotonin and acetylcholine stimulate and GABA inhibits shelf reorientation.”

“An action on the GABA synapse may account for alterations in the effects of other neurotransmitters, such as norepinephrine, serotonin , and acetylcholine.”